In a large bowl, combine beef, bread crumbs, barbecue sauce, egg, seasoning salt, onion powder and garlic powder.
Divide beef mixture into 4 sections and shape into patties (keep in mind they will shrink, so try to make them on the larger side).
Add patties to air fryer basket (you may have to work in batches depending on the size of your air fryer) and cook for 4-5 minutes per side (you don't have to flip, but they will brown evenly on both sides if you do), until an internal temperature of 160 degrees F is reached.